BAKER BROS. ADVISORS LP
Director, 10% Owner | SEC CIK: 0001263508
Comprehensive Trading Performance Summary
The investment footprint of BAKER BROS. ADVISORS LP as disclosed via official SEC Form 4 filings provides a critical window into professional capital allocation strategies. By tracking this specific portfolio, investors can analyze how this individual moves capital across different boards and sectors. High-conviction moves by key stakeholders often serve as leading indicators for future market performance, as they reflect the intimate operational knowledge and fiduciary confidence of those closest to the company's decision-making process. Monitoring these strategic accumulation or exit patterns helps bridge the gap between institutional boardrooms and the retail investment community.
| Filing Date | Trade Date | Ticker | Company Name | Industry | Relationship | Type | Price | Qty | Total, $ | Owned After | Change, % |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-12-20 00:06 | 2025-12-18 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $23.00 | 2,608,696 | $60,000,008 | 18,358,772 | +16.6% |
| 2025-12-12 00:19 | 2025-12-11 | KYMR | Kymera Therapeutics, Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $86.00 | 2,005,813 | $172,499,918 | 7,955,916 | +33.7% |
| 2025-11-25 00:09 | 2025-11-20 | TRDA | Entrada Therapeutics, Inc. | Pharmaceutical Preparations | 10% owner | BUY | $9.07 | 28,867 | $261,847 | 4,691,392 | +0.6% |
| 2025-11-13 01:34 | 2025-11-10 | TRDA | Entrada Therapeutics, Inc. | Pharmaceutical Preparations | 10% owner | BUY | $7.60 | 178,044 | $1,352,582 | 4,664,924 | +4.0% |
| 2025-10-02 23:47 | 2025-09-30 | KALA | KALA BIO, Inc. | Pharmaceutical Preparations | Other | SELL | $1.45 | 730,408 | $1,056,754 | 425,006 | -63.2% |
| 2025-09-10 23:06 | 2025-09-08 | CELC | Celcuity Inc. | Services-Medical Laboratories | 10% owner | BUY | $56.27 | 170,100 | $9,571,323 | 7,211,484 | +2.4% |
| 2025-08-21 01:12 | 2025-08-18 | MDGL | MADRIGAL PHARMACEUTICALS, INC. | Pharmaceutical Preparations | Director | BUY | $380.58 | 97,065 | $36,941,202 | 1,947,968 | +5.2% |
| 2025-08-21 01:09 | 2025-08-18 | MDGL | MADRIGAL PHARMACEUTICALS, INC. | Pharmaceutical Preparations | Director | BUY | $364.04 | 68,618 | $24,979,827 | 1,859,091 | +3.8% |
| 2025-07-01 03:15 | 2025-06-30 | KYMR | Kymera Therapeutics, Inc. | Biological Products, (No Diagnostic Substances) | Director | BUY | $44.00 | 655,500 | $28,842,000 | 6,117,295 | +12.0% |
| 2025-03-20 01:40 | 2025-03-17 | IMCR | Immunocore Holdings plc | Biological Products, (No Diagnostic Substances) | Director | BUY | $29.72 | 807,338 | $23,993,197 | 2,144,060 | +60.4% |
| 2025-03-01 05:28 | 2025-02-28 | ONC | BeOne Medicines Ltd. | Pharmaceutical Preparations | Director | SELL | $260.00 | 732,827 | $190,535,020 | 8,068,411 | -8.3% |
| 2025-01-01 00:00 | 2024-12-30 | KALA | KALA BIO, Inc. | Pharmaceutical Preparations | 10% owner | BUY | $6.44 | 310,559 | $2,000,000 | 1,083,398 | +40.2% |
| 2024-12-18 02:03 | 2024-12-13 | BCYC | BICYCLE THERAPEUTICS PLC | Pharmaceutical Preparations | Director, 10% owner | BUY | $14.29 | 1,485,397 | $21,230,334 | 9,995,274 | +17.5% |
| 2024-12-11 05:25 | 2024-12-09 | BGNE | BeOne Medicines Ltd. | Pharmaceutical Preparations | Director | SELL | $187.27 | 1,037,017 | $194,199,996 | 8,740,387 | -10.6% |
| 2024-08-22 23:03 | 2024-08-20 | KYMR | Kymera Therapeutics, Inc. | Biological Products, (No Diagnostic Substances) | Director | BUY | $46.41 | 1 | $46 | 5,516,986 | +0.0% |
| 2024-03-29 02:04 | 2024-03-26 | IGMS | N/A | Other | Director, 10% owner | BUY | $8.67 | 395,317 | $3,425,580 | 3,753,480 | +11.8% |
| 2023-12-16 01:32 | 2023-12-13 | IGMS | N/A | Other | Director, 10% owner | BUY | $6.44 | 532,693 | $3,431,448 | 3,390,323 | +18.6% |
| 2023-12-15 02:10 | 2023-12-13 | MDGL | MADRIGAL PHARMACEUTICALS, INC. | Pharmaceutical Preparations | Director | BUY | $221.20 | 101,792 | $22,516,574 | 1,793,403 | +6.0% |
| 2023-12-15 02:09 | 2023-12-12 | MDGL | MADRIGAL PHARMACEUTICALS, INC. | Pharmaceutical Preparations | Director | BUY | $218.31 | 34,578 | $7,548,616 | 1,699,129 | +2.1% |
| 2023-11-22 02:15 | 2023-11-21 | MDGL | MADRIGAL PHARMACEUTICALS, INC. | Pharmaceutical Preparations | Director | BUY | $188.47 | 64,350 | $12,128,341 | 1,667,104 | +4.0% |
| 2023-11-22 02:14 | 2023-11-17 | MDGL | MADRIGAL PHARMACEUTICALS, INC. | Pharmaceutical Preparations | Director | BUY | $178.11 | 67,079 | $11,947,280 | 1,607,668 | +4.4% |
| 2023-11-16 01:13 | 2023-11-14 | MDGL | MADRIGAL PHARMACEUTICALS, INC. | Pharmaceutical Preparations | Director | BUY | $158.13 | 49,387 | $7,809,556 | 1,545,775 | +3.3% |
| 2023-11-16 01:12 | 2023-11-13 | MDGL | MADRIGAL PHARMACEUTICALS, INC. | Pharmaceutical Preparations | Director | BUY | $146.99 | 107,499 | $15,801,020 | 1,500,227 | +7.7% |
| 2023-11-15 01:54 | 2023-11-14 | BGNE | BeOne Medicines Ltd. | Pharmaceutical Preparations | Director, 10% owner | SELL | $180.50 | 1,100,000 | $198,550,000 | 9,691,294 | -10.2% |
| 2023-10-23 23:49 | 2023-10-19 | BCEL | N/A | Other | Other | SELL | $0.40 | 274,739 | $110,582 | 2,971,128 | -8.5% |
| 2023-08-18 00:08 | 2023-08-15 | NLTX | Neurogene Inc. | Pharmaceutical Preparations | Director, 10% owner | BUY | $0.64 | 2,285,342 | $1,463,533 | 5,612,949 | +68.7% |
| 2023-05-25 00:09 | 2023-05-22 | ACAD | Acadia Pharmaceuticals Inc. | Pharmaceutical Preparations | Director, 10% owner | BUY | $25.33 | 896,522 | $22,707,109 | 39,317,673 | +2.3% |
| 2022-06-07 00:08 | 2022-06-02 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $7.77 | 572,349 | $4,448,182 | 15,967,504 | +3.7% |
| 2022-06-07 00:07 | 2022-06-02 | TRDA | Entrada Therapeutics, Inc. | Pharmaceutical Preparations | 10% owner | BUY | $6.37 | 40,947 | $260,759 | 4,501,658 | +0.9% |
| 2022-05-27 23:44 | 2022-05-25 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $6.75 | 350,406 | $2,363,734 | 15,455,507 | +2.3% |
| 2022-05-25 01:39 | 2022-05-20 | TRDA | Entrada Therapeutics, Inc. | Pharmaceutical Preparations | 10% owner | BUY | $5.82 | 48,509 | $282,449 | 4,465,029 | +1.1% |
| 2022-05-19 00:38 | 2022-05-16 | TRDA | Entrada Therapeutics, Inc. | Pharmaceutical Preparations | 10% owner | BUY | $5.99 | 71,944 | $430,700 | 4,421,689 | +1.7% |
| 2022-05-19 00:30 | 2022-05-16 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $5.91 | 456,690 | $2,696,846 | 15,142,074 | +3.1% |
| 2022-05-12 23:41 | 2022-05-10 | TCRX | TScan Therapeutics, Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $1.88 | 1,359,792 | $2,559,129 | 2,528,583 | +116.3% |
| 2022-03-11 02:02 | 2022-03-08 | INCY | INCYTE CORP | Services-Commercial Physical & Biological Research | Director, 10% owner | BUY | $72.24 | 389,080 | $28,107,762 | 33,419,055 | +1.2% |
| 2022-02-23 01:45 | 2022-02-17 | INCY | INCYTE CORP | Services-Commercial Physical & Biological Research | Director, 10% owner | BUY | $67.96 | 525,804 | $35,734,902 | 33,039,604 | +1.6% |
| 2022-02-18 01:33 | 2022-02-15 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $54.45 | 400,965 | $21,832,143 | 14,734,965 | +2.8% |
| 2022-02-15 01:23 | 2022-02-10 | INCY | INCYTE CORP | Services-Commercial Physical & Biological Research | Director, 10% owner | BUY | $66.91 | 1,598,374 | $106,952,479 | 32,531,489 | +5.2% |
| 2022-02-01 01:06 | 2022-01-27 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $52.02 | 347,665 | $18,084,699 | 14,364,512 | +2.5% |
| 2022-01-26 01:40 | 2022-01-21 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $57.49 | 501,111 | $28,806,817 | 14,027,837 | +3.7% |
| 2021-12-18 02:30 | 2021-12-15 | INCY | INCYTE CORP | Services-Commercial Physical & Biological Research | Director, 10% owner | BUY | $72.43 | 1,595,519 | $115,558,974 | 30,932,696 | +5.4% |
| 2021-12-03 02:51 | 2021-11-30 | SGEN | N/A | Other | Director, 10% owner | SELL | $160.54 | 394,895 | $63,396,404 | 42,947,504 | -0.9% |
| 2021-11-20 00:09 | 2021-11-18 | TLIS | N/A | Other | Director, 10% owner | BUY | $4.37 | 50,000 | $218,250 | 7,053,176 | +0.7% |
| 2021-10-01 23:58 | 2021-09-30 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $95.83 | 86,932 | $8,330,572 | 13,526,726 | +0.6% |
| 2021-09-18 01:05 | 2021-09-15 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $94.39 | 31,838 | $3,005,281 | 13,300,993 | +0.2% |
| 2021-09-10 01:43 | 2021-09-07 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $93.31 | 57,501 | $5,365,229 | 13,269,155 | +0.4% |
| 2021-08-20 00:12 | 2021-08-17 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $87.50 | 114,396 | $10,009,959 | 13,211,654 | +0.9% |
| 2021-08-14 02:14 | 2021-08-11 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $87.19 | 102,773 | $8,960,624 | 13,097,258 | +0.8% |
| 2021-07-22 23:06 | 2021-07-20 | TCRX | TScan Therapeutics, Inc. | Biological Products, (No Diagnostic Substances) | Director | BUY | $15.00 | 1,425,000 | $21,375,000 | 1,320,302 | +100.0% |
| 2021-07-01 02:29 | 2021-06-28 | KOD | Kodiak Sciences Inc. | Biological Products, (No Diagnostic Substances) | Director, 10% owner | BUY | $91.72 | 257,929 | $23,656,423 | 12,994,485 | +2.0% |
Tracking Multi-Role Insiders: BAKER BROS. ADVISORS LP
High-level stakeholders like BAKER BROS. ADVISORS LP, whether acting as directors, officers, or 10% owners, often possess unique cross-sector insights. Monitoring a specific CIK like 0001263508 allows investors to identify recurring patterns of trading success across various industries. When a large 10% shareholder or a key beneficial owner moves capital, it often signals a strategic shift in institutional or private conviction.
SEC Transparency for Key Stakeholders
Every market move made by BAKER BROS. ADVISORS LP is a matter of public record under federal law. By aggregating Form 4 filings, we provide transparency into the portfolios of major players who hold significant influence. Following the money of those with a 10% stake or executive power helps bridge the information gap between the boardroom and the retail investor.
UNDERSTANDING THE DATA
FILING DATE: The date and time when the transaction was reported to the SEC. This is when the public first receives the information.
TRADE DATE: The actual day the insider executed the purchase or sale in the market.
INDUSTRY: The specific market sector the company operates in. Useful for identifying broader institutional capital flows across sectors.
OWNED AFTER: The total number of shares held by the insider following the transaction. This highlights the insider's remaining conviction in the company.
CHANGE %: The percentage increase or decrease of the insider's total position. Large percentage changes often carry more weight than the dollar amount alone.
TRADE TYPES DEFINITIONS
BUY: An open market purchase. Typically indicates an insider's belief that the stock is undervalued or poised for growth.
SELL: An open market sale. While often used for diversification or liquidity, large or unexpected sales can be a warning signal.
OPT+S (OPTION EXERCISE & SALE): This occurs when an insider exercises their stock options and sells them immediately. Often part of a structured compensation plan.